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We recommend wearing dentures during waking hours and removing at night to soak in a cleanser such as Polident or Novadent. In addition to being a good time to clean the dentures, this allows your oral tissues time to rest and relax. In the morning after soaking in the cleaner, give your dentures some stimulation with a denture brush and after cleansing your oral tissues, wear your dentures throughout the day. In the case of partial dentures, in addition to the above steps, great practice to rinse between meals.